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Crystal Pharmatech’s November 4 announcement confirms ED-1 service in Suzhou. Its service page describes integration with solid-form screening for small crystals and pharmaceutical solid forms.
A Frontiers in Chemistry review examines pharmaceutical cocrystals as a way to modify dissolution and related biopharmaceutical properties without changing an API's chemical identity. The abstract distinguishes solubility-limited BCS II drugs from permeability-limited BCS IV drugs. It highlights gastrointestinal instability, manufacturing reproducibility, coformer selection, and limited pharmacokinetic evidence. Much of the reported performance evidence remains preclinical.
An AAPS Open study used a compaction simulator to track reversible density changes in urea between 600 and 900 MPa, consistent with its known form I-to-III transformation. The original abstract proposes in-die density monitoring as a material-sparing screen for pressure-induced phase changes. Applicability depends on a sufficiently large density difference; urea is the demonstrated model compound.
Researchers produced spherical cyclandelate and cyclandelate–tenoxicam particles in water using thermally induced liquid–liquid phase separation. Stirring controlled droplet and particle-size distributions. Under selected conditions, angles of repose fell by roughly 43%–46% versus raw materials. The study combines particle measurements with molecular simulations; it does not establish improved clinical performance or commercial-scale manufacturability.
Quantum Design reported measuring about 650 dapsone crystals in 24 hours with an ELDICO ED-1. Its case study describes solving Form VI, a form not predicted by the cited CSP studies. This is a vendor-reported demonstration, not a general success-rate benchmark.
A study in npj Computational Materials combines normalizing flows with targeted Bennett acceptance ratio calculations to estimate molecular-crystal lattice free energies. Validation on succinic acid, veliparib, and mivebresib agreed closely with the Einstein crystal method while reducing computational cost. The approach addresses anharmonic free-energy ranking rather than relying only on static lattice energies.
Researchers combined pyridoxine hydrochloride with mesalamine or acetazolamide and p-aminobenzoic acid to prepare ternary eutectic solids. The systems altered pH-dependent solubility and membrane permeability. Characterization distinguished a physical mixture from a cocrystal-containing eutectic, emphasizing that multicomponent formulations can have different phase identities. The reported laboratory results do not establish human bioavailability improvements.
A study of ivacaftor examined how solvent identity, liquid-additive volume, milling time, and starting solid form affect mechanochemical solvate formation. Crystalline Form C and amorphous material followed different transformation patterns. Structural and surface analyses suggest that mechanically exposed polar groups contribute to solvent incorporation, rather than solvent class or apparent dissolution capacity alone explaining the outcome.
Researchers developed a calix[4]arene-based supramolecular gel whose assembly is triggered by dihydrogen phosphate. A salt cocrystal containing furosemide and its tetrabutylammonium salt grew within the gel at a lower furosemide concentration than required in the corresponding solution. The work demonstrates a crystallization environment, rather than a clinically validated pharmaceutical formulation or a ready-to-use manufacturing process.
Researchers characterized eight sotorasib solvates, including three previously unreported forms, using single-crystal diffraction and complementary thermal methods. Despite substantial structural similarities among most solvates, solvent removal led to different anhydrous-polymorph pathways. Experiments and molecular simulations point to local packing environments and thermal history as important factors, showing that similar solvates need not behave identically during drying.
A Crystal Growth & Design study combines CSP, force-field and lattice-dynamics calculations, machine-learning energy corrections, and scaled partition functions to model mixed crystals of anthracene, acridine, and phenazine. It reproduces key experimental binary trends and a ternary phase while predicting additional stable compositions. The validation uses model molecular systems rather than pharmaceutical drug products.
Researchers combined terahertz spectroscopy, Born–Oppenheimer molecular dynamics, and interpretable deep learning to monitor salt formation in an 8-hydroxyquinolinium salicylate model system. Measurements across 80–300 K helped assign lattice-vibration features and establish a stage-resolved analytical workflow. The study is a model-system demonstration of process monitoring, rather than evidence of deployment across commercial active pharmaceutical ingredient processes.
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