Ivacaftor study links milling-induced solvates to starting form and crystal surfaces
Academic source · Crystal Growth & Design (ACS)
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Site published: 2026-11-03 · Updated: 2026-11-03
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What changed
A study of ivacaftor examined how solvent identity, liquid-additive volume, milling time, and starting solid form affect mechanochemical solvate formation. Crystalline Form C and amorphous material followed different transformation patterns. Structural and surface analyses suggest that mechanically exposed polar groups contribute to solvent incorporation, rather than solvent class or apparent dissolution capacity alone explaining the outcome.
Why it may matter
Solid-form screening for milling processes should consider starting material and surface chemistry, not rely solely on solvent classifications.
The interpretation above is analysis, not a conclusion attributed to the original source.
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