Compaction density reveals reversible urea polymorph changes under pressure
Academic source · AAPS Open
Source published: · Event / reporting date: 2026-11-02
Site published: 2026-11-06 · Updated: 2026-11-06
This source is linked automatically. Choose a question to get started.
What the paper reports
An AAPS Open study used a compaction simulator to track reversible density changes in urea between 600 and 900 MPa, consistent with its known form I-to-III transformation. The original abstract proposes in-die density monitoring as a material-sparing screen for pressure-induced phase changes. Applicability depends on a sufficiently large density difference; urea is the demonstrated model compound.
Why this paper is included
Analysis: This approach may help formulation teams flag compression-sensitive solid forms that would otherwise escape analysis after pressure is released.
The interpretation above is analysis, not a conclusion attributed to the original source.
Read the original source ↗Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections
Pharmaceutical solid state Formulation Development & Manufacturing