Water-based spherical crystallization improves drug-particle flow
Academic source · Crystal Growth & Design (ACS)
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What changed
Researchers produced spherical cyclandelate and cyclandelate–tenoxicam particles in water using thermally induced liquid–liquid phase separation. Stirring controlled droplet and particle-size distributions. Under selected conditions, angles of repose fell by roughly 43%–46% versus raw materials. The study combines particle measurements with molecular simulations; it does not establish improved clinical performance or commercial-scale manufacturability.
Why it may matter
The approach offers a solvent-reduction and powder-handling lead, with scale-up, robustness, and downstream formulation performance still needing validation.
The interpretation above is analysis, not a conclusion attributed to the original source.
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