Related sotorasib solvates follow different pathways to anhydrous polymorphs
Academic source · Crystal Growth & Design (ACS)
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Site published: 2026-11-03 · Updated: 2026-11-03
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What changed
Researchers characterized eight sotorasib solvates, including three previously unreported forms, using single-crystal diffraction and complementary thermal methods. Despite substantial structural similarities among most solvates, solvent removal led to different anhydrous-polymorph pathways. Experiments and molecular simulations point to local packing environments and thermal history as important factors, showing that similar solvates need not behave identically during drying.
Why it may matter
Drying and solvent-exchange strategies may need form-specific controls, even when precursor solvates appear structurally similar by routine crystallographic comparison.
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