Supramolecular gel supports furosemide salt-cocrystal growth at lower concentration
Academic source · Crystal Growth & Design (ACS)
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Site published: 2026-11-03 · Updated: 2026-11-03
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What changed
Researchers developed a calix[4]arene-based supramolecular gel whose assembly is triggered by dihydrogen phosphate. A salt cocrystal containing furosemide and its tetrabutylammonium salt grew within the gel at a lower furosemide concentration than required in the corresponding solution. The work demonstrates a crystallization environment, rather than a clinically validated pharmaceutical formulation or a ready-to-use manufacturing process.
Why it may matter
Gel-assisted growth could expand solid-form screening options, although process scale-up and removal of nonpharmaceutical components remain practical questions.
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