Crushed tadalafil formulation retains measured solid-state properties during a 90-day storage study
Academic source · Journal of Pharmaceutical Health Care and Sciences
Source published:
Site published: 2026-11-08 · Updated: 2026-11-08
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What the paper reports
Japanese researchers evaluated crushed tadalafil tablets mixed with lactose at 40 mg/g during 90 days at 25°C under defined humidity and lighting conditions. Thermal analysis and powder X-ray diffraction showed no appreciable changes in thermal behavior or crystalline state. The findings concern the tested preparation and conditions; they do not establish clinical equivalence or a general storage period for other formulations.
Why this paper is included
Potential business implication: combining solid-state and moisture measurements may strengthen pediatric formulation assessments, with chemical, microbiological, and clinical questions requiring separate evidence.
The interpretation above is analysis, not a conclusion attributed to the original source.
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Formulation Development & Manufacturing Pharmaceutical solid state