Chemometric screening leads to a gemfibrozil cocrystal with faster dissolution
Academic source · Crystal Growth & Design
Source published: · Event / reporting date: 2026-11-03
Site published: 2026-11-08 · Updated: 2026-11-08
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What the paper reports
Researchers used Raman spectroscopy and chemometrics to screen fibrate cocrystals, then solved a 1:1 gemfibrozil–isonicotinamide structure by single-crystal X-ray diffraction. A low-solvent vortex-slurry process produced gram quantities. The cocrystal dissolved faster at pH 4.5 but showed no equilibrium solubility advantage at pH 1.2 or 4.5. Findings are laboratory results described in the abstract.
Why this paper is included
Potential business implication: the workflow may streamline cocrystal development while showing why faster dissolution should be evaluated separately from equilibrium solubility.
The interpretation above is analysis, not a conclusion attributed to the original source.
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Pharmaceutical solid state Formulation Development & Manufacturing