Polymer flocculation study targets high-risk host cell proteins during antibody recovery
Academic source · Biotechnology Progress / PubMed
Source published: · Event / reporting date: 2026-11-02
Site published: 2026-11-08 · Updated: 2026-11-08
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What the paper reports
An abstract reports screening five cationic flocculants and comparing antibody recovery across four monoclonal antibodies. Polymer X maintained yields above 95% for three antibodies, removed over 99% of host-cell DNA, reduced total host cell proteins by up to 40%, and removed selected high-risk proteins by over 90%. Findings concern process experiments rather than universal platform performance.
Why this paper is included
Earlier impurity reduction could simplify downstream purification, subject to product-specific validation of recovery, residual impurities, and process consistency.
The interpretation above is analysis, not a conclusion attributed to the original source.
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