Direct-infusion method accelerates antibody peptide mapping in a peer-reviewed study
Academic source · Communications Chemistry
Source published: · Event / reporting date: 2026-11-06
Site published: 2026-11-07 · Updated: 2026-11-07
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What the paper reports
A Communications Chemistry study reports RaPiD-mAb-MS, combining plate-based preparation with direct-infusion mass spectrometry for antibody peptide mapping. The original abstract describes analysis of 96 samples in about 1.5–2 hours, routinely exceeding 95% sequence coverage, across 28 antibodies and more than 2,000 samples. The reported comparisons cover several modifications and sequence variants; broader method suitability still requires evaluation.
Why this paper is included
Analysis: Higher-throughput mapping may shorten developability and formulation screens, while comparability, sensitivity, and quality-control validation remain application-specific requirements.
The interpretation above is analysis, not a conclusion attributed to the original source.
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