Cell-free Arc capsids deliver gene editors and restore dystrophin expression in mice
Academic source · Nature Communications
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Site published: 2026-11-08 · Updated: 2026-11-08
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What the paper reports
A Nature Communications study assembled Drosophila Arc1 capsids from purified proteins and transcribed RNA. Engineered particles packaged mRNA or Cas9 ribonucleoproteins and interacted with mammalian SORCS2 receptors. Intramuscular delivery of Cas9 cargo produced up to 18% exon skipping and restored dystrophin expression in mdx mice. The findings demonstrate preclinical delivery feasibility, not human efficacy or systemic muscle targeting.
Why this paper is included
Potential business implication: defined protein-particle assembly may create alternative delivery and analytical-development opportunities, while scale, immunogenicity, and broader biodistribution require further validation.
The interpretation above is analysis, not a conclusion attributed to the original source.
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