A Combinatorial mRNA Therapy for Treating Rheumatoid Arthritis and Osteoarthritis by Inhibiting Inflammation and Preventing Cartilage Degeneration
Wang G; Guo Y; Guo K; Zhang C; Zhou Y; Xia J; Jiang H; Liu J; Ren J; Mohamed AO; Tang K; Chen X; Sun S; Xing Y; Yang Y; Shen M; Wang R; Huang Y; Li X; Lin A Molecular therapy : the journal of the American Society of Gene Therapy · DOI 10.1016/j.ymthe.2026.10.021
Lipid nanoparticle-mediated co-delivery of human RB1 mRNA and triptolide for localized genetic therapy of retinoblastoma
Chun K; Choi SY; An K; Jo DH; Lee H Journal of controlled release : official journal of the Controlled Release Society · DOI 10.1016/j.jconrel.2026.115453
Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI
Jinbi Tian; Khanh T. M. Tran; Brett H. Pogostin; Olivia Sheridan; Sevinj Mursalova; Amy H. Lee; Shuai Liu; Jaya Hamkins; Daniel Antov; Alana L. Power; Zane S. Dash; Dongsoo Yun; Mina Konaković Luković; Robert S. Langer; Ana Jaklenec Nature Biotechnology · DOI 10.1038/s41587-026-03331-w
Lipid Nanoparticle Surface Engineering with Heparosan Polysaccharides Enhances mRNA Efficacy via Reduced Endosomal Retention
Yuxin He; Lin Wang; Abigael P. Williams; Trisha I. Valerio; Yuanhong Sun; James Bowman; Samantha D. Ricketts; Savannah Hammond; Aidan Sison; Jezan Alexandre; Zachary Niastor; Wei R. Chen; Dixy E. Green; Kar-Ming Fung; Paul L. DeAngelis; Stefan Wilhelm ACS nano · DOI 10.1021/acsnano.6c11865
Intratumoral injection of EpCAM BITE, IL-12, and GM-CSF mRNA-LNPs blocks the growth of local treated and distant untreated tumors
Vita Golubovskaya; Liang Hu; Shiming Zhang; John Sienkiewicz; Hua Zhou; Robert Berahovich; Jinying Sun; Le Li; Walter Bodmer; Lijun Wu Proceedings of the National Academy of Sciences of the United States of America · DOI 10.1073/pnas.2616059123
Overcoming the blood–brain barrier using central nervous system–accessing lipid nanoparticles for enhanced mRNA therapeutics
Siyu Wang; Yichen Zhong; Chang Wang; Meng Tian; Jeffrey L. Bennett; Eliza Bliss-Moreau; Yonger Xue; Changyue Yu; Xucheng Hou; Ya Ying Zheng; Haoyuan Li; Zhengwei Liu; Dinglingge Cao; Diana D. Kang; Binbin Deng; Yizhou Dong Proceedings of the National Academy of Sciences · DOI 10.1073/pnas.2538147123
