Simple heat-assisted method for mRNA loading into empty lipid nanoparticles enables robust in vitro and in vivo delivery
Takayuki Miyazaki; Kenji Kubara; Keita Kondo; Hiroshi Kamiyama; Shoki Hara; Jun Moriya; Hiroshi Ishihara; Yuta Suzuki International Journal of Pharmaceutics · DOI 10.1016/j.ijpharm.2026.127599
An mRNA–lipid nanoparticle vaccine against H5N1 influenza virus protects lactating dairy cows from infection
Jefferson J. S. Santos; Carine K. Souza; Giovana C. Zanella; Débora B. Goulart; Bailey Arruda; Paola Boggiatto; Mitchell V. Palmer; Celeste A. Snyder; Michaela A. Kristula; Charlene Dickens; Terry L. Webb; Reilly K. Atkinson; Bernadeta Dadonaite; Garima Dwivedi; Mohamad-Gabriel Alameh; Christopher A. Hunter; Lisa A. Murphy; Jesse D. Bloom; Drew Weissman; Gary C. Althouse; Amy L. Baker; Scott E. Hensley Nature Biotechnology · DOI 10.1038/s41587-026-03343-6
Uncovering the lymphatic uptake, pharmacokinetics, and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection
Peng Li; Mohammad Abdallah; Yuxin Yao; Rekha Shandre Mugan; Thomas J. Payne; Stewart A. Fabb; Colin W. Pouton; Natalie L. Trevaskis Journal of controlled release : official journal of the Controlled Release Society · DOI 10.1016/j.jconrel.2026.115491
Programmable mRNA vaccine materials for temporal control of antitumour immunity
Seong Dong Jeong; Chaoyang Tang; Xiaotian Wang; Antoni J. Szeglowski; Yujin Kim; B. J. Kim; Padmanee Sharma; James J. Moon; Wen Jiang; Betty Y. S. Kim Nature Reviews Materials · DOI 10.1038/s41578-026-00974-8
A Scalable, Antibody-Free Lipid Nanoparticle Achieves Preferential mRNA Delivery to Human HSPCs In Vivo Without Conditioning
Kim E; Zenhausern R; Kapadia S; Johnson S; Cho S; Choi J; Park K; Diaz E; Podilapu AR; Kuppan R; Dahlman JE; Kim H; Woo J Molecular therapy : the journal of the American Society of Gene Therapy · DOI 10.1016/j.ymthe.2026.10.024
A Combinatorial mRNA Therapy for Treating Rheumatoid Arthritis and Osteoarthritis by Inhibiting Inflammation and Preventing Cartilage Degeneration
Wang G; Guo Y; Guo K; Zhang C; Zhou Y; Xia J; Jiang H; Liu J; Ren J; Mohamed AO; Tang K; Chen X; Sun S; Xing Y; Yang Y; Shen M; Wang R; Huang Y; Li X; Lin A Molecular therapy : the journal of the American Society of Gene Therapy · DOI 10.1016/j.ymthe.2026.10.021
Preparation quality and epitranscriptomic modification influence circular RNA vaccine performance
Abby L. Martin; Jessica F. Cotterell; Kaitlin H. Buick; Thomas W. Bird; Joanna Kuang; Olga R. Palmer; Ngarangi C. Mason; Lydia White; Sarah L. Draper; Amy J. Foster; Gavin F. Painter; Isabelle Montgomerie; Tifany Oulavallickal; Wayne M. Patrick; Lisa M. Connor npj Vaccines · DOI 10.1038/s41541-026-01581-y
