Simple heat-assisted method for mRNA loading into empty lipid nanoparticles enables robust in vitro and in vivo delivery
Takayuki Miyazaki; Kenji Kubara; Keita Kondo; Hiroshi Kamiyama; Shoki Hara; Jun Moriya; Hiroshi Ishihara; Yuta Suzuki International Journal of Pharmaceutics · DOI 10.1016/j.ijpharm.2026.127599
Uncovering the lymphatic uptake, pharmacokinetics, and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection
Peng Li; Mohammad Abdallah; Yuxin Yao; Rekha Shandre Mugan; Thomas J. Payne; Stewart A. Fabb; Colin W. Pouton; Natalie L. Trevaskis Journal of controlled release : official journal of the Controlled Release Society · DOI 10.1016/j.jconrel.2026.115491
Programmable mRNA vaccine materials for temporal control of antitumour immunity
Seong Dong Jeong; Chaoyang Tang; Xiaotian Wang; Antoni J. Szeglowski; Yujin Kim; B. J. Kim; Padmanee Sharma; James J. Moon; Wen Jiang; Betty Y. S. Kim Nature Reviews Materials · DOI 10.1038/s41578-026-00974-8
A Scalable, Antibody-Free Lipid Nanoparticle Achieves Preferential mRNA Delivery to Human HSPCs In Vivo Without Conditioning
Kim E; Zenhausern R; Kapadia S; Johnson S; Cho S; Choi J; Park K; Diaz E; Podilapu AR; Kuppan R; Dahlman JE; Kim H; Woo J Molecular therapy : the journal of the American Society of Gene Therapy · DOI 10.1016/j.ymthe.2026.10.024
PEG-associated efficacy loss in lipid nanoparticles persists across formulation modifications for mRNA delivery
Mariah L. Arral; Namit Chaudhary; Katherine C. Fein; Alexandra N. Newby; Saigopalakrishna S. Yerneni; Jilian R. Melamed; Samuel T. LoPresti; Daria M. Strelkova Petersen; Kathryn A. Whitehead Drug delivery and translational research · DOI 10.1007/s13346-026-02225-3
Circular RNA Delivery In Vitro and In Vivo Using Doubly Branched Aminoethoxy-Functionalized Ionizable Lipid Nanoparticles
Adam Cook; Pavan K. Yadav; Ekram W. Helmy; Kseniia Vlasova; Howard Y. Chang; Paul A. Wender Journal of the American Chemical Society · DOI 10.1021/jacs.6c14175
