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Oral cyclic peptides 2

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Methods
Bioconjugate Chemistry

Synthesis of DNA-Encoded Bicyclic Peptides via Cysteine-Promoted Cyclization and Amide Condensation Reaction

Yi Gan; Yumei Zeng; Haojie Guan; Wenjun Li; Alex Shaginian; Jin Li; Sen Gao; Guansai Liu

HitGen researchers describe a method for synthesizing DNA-encoded bicyclic peptides using cysteine-promoted cyclization and amide condensation under mild conditions. The abstract reports compatibility with varied sequences and ring sizes. This is discovery-platform chemistry, not evidence that the resulting peptides have oral exposure, clinical efficacy, or validated manufacturing-scale performance.

China-listed CRO/CDMOOral cyclic peptides
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DOI: 10.1021/acs.bioconjchem.5c00455

Original research
New England Journal of Medicine

An Oral Interleukin-23–Receptor Antagonist Peptide for Plaque Psoriasis

Robert Bissonnette; Andreas Pinter; Laura K Ferris; Sascha Gerdes; Phoebe Rich; Ronald Vender; Megan Miller; Yaung-Kaung Shen; Arun Kannan; Shu Li; Cynthia DeKlotz; Kim Papp

A randomized phase 2 study evaluated oral JNJ-77242113, an IL-23 receptor antagonist peptide, against placebo for 16 weeks in plaque psoriasis. The study reported a dose-response relationship for skin improvement. This is candidate-specific human evidence; it does not establish oral bioavailability or clinical success for other cyclic peptides.

Oral cyclic peptides
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DOI: 10.1056/nejmoa2308713

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