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An Oral Interleukin-23–Receptor Antagonist Peptide for Plaque Psoriasis

Academic source · New England Journal of Medicine

Source published: · Event / reporting date: 2024-02-07

Site published: 2026-11-04 · Updated: 2026-11-04

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What the paper reports

A randomized phase 2 study evaluated oral JNJ-77242113, an IL-23 receptor antagonist peptide, against placebo for 16 weeks in plaque psoriasis. The study reported a dose-response relationship for skin improvement. This is candidate-specific human evidence; it does not establish oral bioavailability or clinical success for other cyclic peptides.

Why this paper is included

A representative human study linking oral peptide design to clinical activity, with molecule-specific limits on generalization.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

Oral cyclic peptides

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