Synthesis of DNA-Encoded Bicyclic Peptides via Cysteine-Promoted Cyclization and Amide Condensation Reaction
Academic source · Bioconjugate Chemistry
Source published: · Event / reporting date: 2025-11-06
Site published: 2026-11-04 · Updated: 2026-11-04
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What the paper reports
HitGen researchers describe a method for synthesizing DNA-encoded bicyclic peptides using cysteine-promoted cyclization and amide condensation under mild conditions. The abstract reports compatibility with varied sequences and ring sizes. This is discovery-platform chemistry, not evidence that the resulting peptides have oral exposure, clinical efficacy, or validated manufacturing-scale performance.
Why this paper is included
Potential research relevance: expands bicyclic library construction options while separating screening chemistry from oral delivery and clinical validation.
The interpretation above is analysis, not a conclusion attributed to the original source.
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