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Peptide amphiphile coassembly alters LNP uptake and tissue targeting in preclinical experiments

Academic source · ACS Applied Materials & Interfaces / PubMed

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Site published: 2026-11-07 · Updated: 2026-11-07

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What the paper reports

An ACS Applied Materials & Interfaces study incorporated charged peptide amphiphiles into mRNA lipid nanoparticles. Cationic C16TAT improved delivery in cell experiments, while anionic C16HA2 produced spleen-selective expression in vivo, exceeding liver expression by more than 100-fold in the reported setting. Tissue targeting depended on substantial changes in particle charge; the abstract does not establish human performance.

Why this paper is included

Potential business implication: amphiphile integration may offer formulation teams another route to tune LNP tropism, requiring reproducibility, stability, and safety evaluation.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

mRNA / LNP Formulation Development & Manufacturing

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