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Icotrokinra: An Oral Interleukin-23 Receptor Antagonist Peptide for the Treatment of Psoriasis

Academic source · American Journal of Clinical Dermatology

Source published: 2026-03-12 · Event / reporting date: 2026-03-12

Site published: 2026-11-07 · Updated: 2026-11-07

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What the paper reports

This narrative review summarizes icotrokinra, an oral macrocyclic IL-23-receptor antagonist, using literature through December 2025 plus conference, company and trial-registry sources. It reviews Phase 2–3 evidence; it is not a new trial or a current regulatory-status assessment.

Why this paper is included

Context for oral macrocyclic peptide translation; historical review backfill.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Oral cyclic peptides

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No explicit catalog company name was matched. These are companies in the same field, not attributed participants.

Triastek Oralead Pharma Syneron Bio Merck / MSD Johnson & Johnson

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Related updates

2026-11-07Johnson & Johnson (PR Newswire)

Icotrokinra meets Phase 3 joint-response endpoint in biologic-naive psoriatic arthritis

Johnson & Johnson reported that 58% of patients receiving icotrokinra 200 mg achieved ACR20 at Week 16 in ICONIC-PsA 1, versus 41% with placebo. The oral IL-23 receptor peptide also showed skin responses. The company reported no new safety signals through Week 24; active psoriatic arthritis remains an investigational indication.

Companies mentionedJohnson & Johnson ↗

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2026-11-06Entera Bio investor filing

Adjacent oral-peptide field: Entera reports $265.9 million cash as EB613 Phase 3 preparations continue

Entera reported $265.9 million in cash and cash equivalents at September 30, plus $6.5 million in restricted cash. Its November 6 update targets first site activation for an approximately 900-patient EB613 osteoporosis Phase 3 trial in late 2026. EB613 is an oral PTH(1-34) program, included here as an adjacent oral-peptide delivery development, not a cyclic-peptide candidate.

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2026-11-06Johnson & Johnson

ICONIC-ASCEND reports icotrokinra noninferiority to ustekinumab in plaque psoriasis

Johnson & Johnson reported that ICONIC-ASCEND met its Week 16 co-primary endpoints: PASI 90 responses were 55.2% with icotrokinra versus 3.6% with placebo, and IGA 0/1 responses were 70.4% versus 9.5%. At Week 28, the oral peptide met noninferiority criteria versus ustekinumab across multiplicity-controlled key secondary skin-clearance endpoints.

Companies mentionedJohnson & Johnson ↗

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