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Precision BioSciences updates ARCUS in vivo editing programs in third-quarter report

Company / institutional announcement · Precision BioSciences

Source published: 2026-11-03

Site published: 2026-11-04 · Updated: 2026-11-04

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What changed

Precision BioSciences updated its ARCUS in vivo editing portfolio in its third-quarter report. The company described ongoing ELIMINATE-B evaluation of PBGENE-HBV and the Phase 1/2 FUNCTION-DMD study of PBGENE-DMD, which uses AAV delivery. Planned data releases and management expectations should be distinguished from completed clinical outcomes.

Why it may matter

Potential business relevance: differentiates delivery approaches and development maturity when evaluating analytical, manufacturing, and translational research needs.

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2026-11-05Precision BioSciences / Business Wire

Safety board supports further PBGENE-DMD dosing after first patient's eight-week review

Precision BioSciences said an independent safety board endorsed additional dosing in the Phase 1/2 FUNCTION-DMD study after reviewing the first PBGENE-DMD recipient's eight-week observation period. No serious adverse events or adverse events of special interest were reported in that patient. The AAV-delivered gene-editing program remains investigational; this single-patient review does not establish efficacy or broader safety.

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2026-11-05Precision BioSciences / Business Wire

Precision reports new ELIMINATE-B gene-editing data and plans Phase 2

Precision BioSciences reported updated PBGENE-HBV Phase 1 data covering 25 patients and 59 administrations. The company described pgRNA loss and liver-biopsy evidence of cccDNA reduction at the expected go-forward dose of 0.4 mg/kg, with no dose-limiting toxicities reported. It plans Phase 2 evaluation, including assessment after nucleos(t)ide analog withdrawal; viral cure has not been established.

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