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Precision reports new ELIMINATE-B gene-editing data and plans Phase 2

Company / institutional announcement · Precision BioSciences / Business Wire

Source published: 2026-11-05 · Event / reporting date: 2026-11-05

Site published: 2026-11-06 · Updated: 2026-11-06

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Findings and limitations Industry implications Related developments

What changed

Precision BioSciences reported updated PBGENE-HBV Phase 1 data covering 25 patients and 59 administrations. The company described pgRNA loss and liver-biopsy evidence of cccDNA reduction at the expected go-forward dose of 0.4 mg/kg, with no dose-limiting toxicities reported. It plans Phase 2 evaluation, including assessment after nucleos(t)ide analog withdrawal; viral cure has not been established.

Why it may matter

Analysis: These early human findings may inform liver-directed editing development, but durability, off-target safety, and treatment-free viral control still require validation.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

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