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Rat study links cyclic-peptide proteolytic stability to absorption with sodium decanoate

Academic source · Molecular Pharmaceutics

Source published: 2026-11-04

Site published: 2026-11-08 · Updated: 2026-11-08

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What the paper reports

Genentech researchers studied two macrocyclic peptide series with sodium decanoate. In vitro, the enhancer reduced pancreatic-enzyme degradation; intrajejunal dosing increased absolute bioavailability in rats. Within the tested series, an approximately 60-minute pancreatin half-life without enhancer was sufficient for maximal absorption with enhancer. The abstract does not establish a human oral-delivery threshold.

Why this paper is included

Potential business implication: paired stability and enhancer testing may help prioritize cyclic-peptide formulation work, subject to route and species validation.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Oral cyclic peptides Formulation Development & Manufacturing

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