Cell-based screen identifies 68 potential activators of circular RNA translation
Academic source · Nature Communications
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Site published: 2026-11-07 · Updated: 2026-11-07
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What the paper reports
A Nature Communications study developed a cell-based screen of RNA-binding proteins and identified 68 putative activators of circular RNA translation. A machine-learning approach predicted additional candidates, with selected proteins subsequently validated for context-dependent enhancement of IRES-mediated translation. These cellular findings expand engineering options but do not establish therapeutic efficacy or safety in animals or humans.
Why this paper is included
Potential business implication: the screen may inform circRNA construct design and comparative expression assays, with delivery and translational validation still required.
The interpretation above is analysis, not a conclusion attributed to the original source.
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