Follow sourced scientific, clinical, partnership, capacity, and financial developments. Factual summaries and business interpretations are presented separately.
Research runs each weekday at 8 a.m. Eastern Time. Channels update when qualifying developments are found. Editorial standards · RSS ↗
An automated molecular-replacement workflow solved the electron-diffraction structure of corilagin, a macrocyclic gallotannin that resisted ab initio phasing. Validation used known paritaprevir and grazoprevir structures across several resolution cutoffs. The results suggest an alternative route for flexible or lower-quality small-molecule datasets, with the important condition that chemically appropriate trial conformations must be available.
Sunshine Guojian discussed its 629 oral IL-23 cyclic peptide program in an investor-relations record, saying pharmacokinetic findings suggest potential for weekly dosing. The document did not provide study species, participant details, quantitative exposure, or clinical outcomes. These are company development claims and do not establish validated human bioavailability, weekly clinical efficacy, or an approved dosing regimen.
Syneron Bio announced a $150 million Series B financing that closed on March 31. An international life-science fund led the round, with Decheng Capital, CDH VGC, and other investors participating. Proceeds will develop Synova and advance oncology, autoimmune, metabolic, and rare-disease programs toward the clinic. Named candidates, enrollment milestones, and human oral pharmacokinetics were not disclosed.
Triastek announced FDA IND clearance for T25, a modified-release oral octreotide acetate tablet intended for maintenance treatment of adults with acromegaly who respond to somatostatin analogs. The candidate combines MED&SSE printing with its 3D microstructure delivery system. Clearance enables clinical development; the announcement did not provide human pharmacokinetic or efficacy results.
Pinnacle Medicines closed an $89 million Series B co-led by LAV and Foresite Capital, bringing disclosed funding to $134 million. Proceeds support oral peptide programs toward clinical proof of concept, initially in immunology and cardiometabolic disease, alongside expansion of AI and physics-based discovery capabilities. The announcement does not provide new human efficacy results.
FDA approved icotrokinra, marketed as ICOTYDE, on March 17; Johnson & Johnson announced the decision the following day. The once-daily oral IL-23 receptor antagonist is indicated for eligible adults and patients aged 12 or older weighing at least 40 kg with moderate-to-severe plaque psoriasis. The approval does not extend to ulcerative colitis or other investigational indications.
Unnatural Products closed a $45 million Series B led by The Venture Collective, with argenx, Droia, and existing investors participating. Funding supports its computational design, automated chemistry, high-throughput screening platform, and macrocyclic peptide pipeline. The oral-delivery strategy remains a development objective; this financing announcement does not establish human oral efficacy for a newly disclosed candidate.
Aurinia reported 2025 net product sales of $271.3 million for LUPKYNIS, up 25%, while company revenue reached $283.1 million, up 20%. Oral voclosporin is approved for adults with active lupus nephritis. The figures distinguish product sales from total revenue and licensing income; commercial growth does not constitute new comparative evidence of clinical benefit.
Unnatural Products licensed an undisclosed cardiovascular program to Novartis. Terms include up to $100 million in upfront and pre-IND payments, plus up to $1.7 billion in later milestones and royalties. The platform supports oral and injectable macrocycles; the announcement does not establish the specific program’s route or imply all contingent payments have been received.
An integrated workflow combined MicroED with high-resolution mass spectrometry, database searches, solution and solid-state NMR, and computational calculations. Demonstrations used a pyridoxine–N-acetyl-L-cysteine salt and the peptide fMLF. The approach addressed molecular identity, crystal packing, light-atom assignment, and hydrogen positions, illustrating how complementary measurements can resolve ambiguities that electron diffraction alone may leave in nanocrystalline powders.
Researchers reported MicroED structures for nine chemically diverse natural products whose three-dimensional structures had remained unavailable. The work used microgram quantities and avoided the need to grow large single crystals. It supports MicroED as a practical route for difficult natural-product samples, although the selected examples do not define a universal success rate across all natural products.
Haisco reported Phase 1 and formulation pharmacokinetic findings for oral IL-23 peptide HSK47388. Exposure with a 50 mg enhancer formulation was comparable to a 200 mg tablet without enhancer, and the company said psoriasis Phase 2 began in fourth-quarter 2025. Public materials identify an oral peptide but do not fully disclose cyclization; relative exposure is not absolute bioavailability.
Continue your research
All company profiles, filters, and comparisons are open. Sign in for private saves and member discussions.
