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Merck reported Phase 3 CORALreef Lipids results showing a 55.8% placebo-adjusted LDL-C reduction at week 24 in the primary analysis. A post hoc reanalysis addressing biologically implausible baseline values estimated 59.7%. LDL-C reductions persisted through week 52. These lipid findings should not be equated with demonstrated reductions in cardiovascular events.
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