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Enlicitide Phase 3 LDL-C results distinguish primary and post hoc analyses

Company / institutional announcement · Merck / MSD

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Site published: 2026-11-03 · Updated: 2026-11-03

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What changed

Merck reported Phase 3 CORALreef Lipids results showing a 55.8% placebo-adjusted LDL-C reduction at week 24 in the primary analysis. A post hoc reanalysis addressing biologically implausible baseline values estimated 59.7%. LDL-C reductions persisted through week 52. These lipid findings should not be equated with demonstrated reductions in cardiovascular events.

Why it may matter

Provides pivotal evidence for an oral PCSK9 macrocycle while showing why primary and post hoc estimates must remain distinguishable.

The interpretation above is analysis, not a conclusion attributed to the original source.

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