Perspective maps oligonucleotide conjugation strategies beyond liver targeting
Academic source · AAPS Open
Source published: · Event / reporting date: 2026-11-02
Site published: 2026-11-06 · Updated: 2026-11-06
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What the paper reports
An AAPS Open perspective surveys conjugation strategies for antisense oligonucleotides and siRNAs, including small-molecule ligands, cell-penetrating peptides, antibodies, and aptamers. The abstract contrasts clinically established GalNAc delivery with emerging approaches to extrahepatic tissues and discusses translation challenges. This is a synthesis of delivery platforms and clinical progress, rather than a new experimental or clinical efficacy study.
Why this paper is included
Analysis: The comparison may support ligand selection and partnering decisions while separating validated liver targeting from less mature extrahepatic delivery approaches.
The interpretation above is analysis, not a conclusion attributed to the original source.
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