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Overcoming technological and biological barriers to pulmonary mRNA delivery with lipid-polymer hybrid nanoparticles

Academic source · Journal of controlled release : official journal of the Controlled Release Society

Source published: 2026-10-30

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

Lipid-polymer hybrid particles combined polymer stability with lipid-mediated transfection. Hyaluronic acid and polyvinyl alcohol coatings helped preserve particle properties after nebulization, while mucus-covered airway cultures retained measurable transfection. Primary human lung fibroblasts and intratracheally dosed mice provided additional delivery evidence. These results support aerosol formulation development, although intratracheal dosing does not establish the performance of inhaled aerosols in patients.

Why this paper is included

Addresses both aerosol stress and airway barriers; inhalation deposition, repeated dosing, and disease-specific efficacy remain important translation gaps.

The interpretation above is analysis, not a conclusion attributed to the original source.

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mRNA / LNP

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