Spray Freeze Drying for Solid Formulations of RNA Lipid Nanoparticles
Academic source · AAPS PharmSciTech
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Using yeast RNA as a model payload, researchers evaluated atomization, freezing, drying temperature, and annealing during spray-freeze drying of RNA-LNPs. Powder diffraction, microscopy, and solid-state NMR supported characterization. Sucrose outperformed trehalose in the tested systems, and annealing improved stability. Because the payload was model RNA, these findings do not directly establish therapeutic mRNA expression potency or clinical-product stability.
Why this paper is included
Offers process guidance for solid RNA formulations; therapeutic mRNA translation requires additional integrity, functional potency, and product-specific stability studies.
The interpretation above is analysis, not a conclusion attributed to the original source.
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