Mannosylated Spleen-Targeted Lipid Nanoparticles Enable Enhanced mRNA Delivery to Antigen-Presenting Cells
Academic source · ACS Biomaterials Science & Engineering
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
A mannose-containing fifth lipid was incorporated into spleen-targeted LNPs to combine endogenous organ enrichment with receptor-associated uptake. Adjusting mannose-lipid content shifted distribution toward the spleen and improved macrophage transfection. Experiments identified uptake by macrophages and conventional dendritic cells, alongside freeze-thaw stability testing. These findings support immune-delivery development, while therapeutic and human targeting performance remain undetermined.
Why this paper is included
Combines ligand targeting and organ-selective formulation in one platform; uptake enrichment alone does not establish clinical immunotherapy efficacy.
The interpretation above is analysis, not a conclusion attributed to the original source.
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