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Tempest outlines targeted mRNA/LNP in vivo CAR-T program and first-trial plan

Company / institutional announcement · Tempest Therapeutics

Source published: · Event / reporting date: 2026-07-15

Site published: 2026-11-03 · Updated: 2026-11-03

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What changed

Tempest outlined TPST-4003, an in vivo CAR-T candidate using CD7-targeted mRNA/LNP delivery of a dual CD19/BCMA CAR. A planned investigator-initiated study would enroll approximately ten patients with nervous-system autoimmune diseases, initially including myasthenia gravis and multiple sclerosis, with dosing anticipated in the fourth quarter. This is a development plan, not human efficacy evidence for the in vivo candidate.

Why it may matter

Targeted LNP delivery could simplify CAR-T production, but effective and safe in vivo T-cell engineering must still be demonstrated in this program.

The interpretation above is analysis, not a conclusion attributed to the original source.

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mRNA / LNP

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