Hidden nuclei undermine the supersaturation advantage of amorphous solid dispersions
Academic source · Molecular Pharmaceutics (ACS)
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Site published: 2026-11-03 · Updated: 2026-11-03
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What changed
Researchers studied flurbiprofen–polyvinylpyrrolidone amorphous solid dispersions using controlled nucleation and real-time synchrotron X-ray diffraction after contact with water. Higher nucleation density shortened the lag before crystallization and accelerated drug crystallization. The work proposes that evaluating latent nuclei is important to maintaining supersaturation, rather than assuming the absence of visible crystals demonstrates a robust amorphous formulation.
Why it may matter
Assessing latent nucleation could improve stability screening and storage decisions for amorphous formulations whose apparent disorder otherwise masks crystallization risk.
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