Myricetin cocrystals highlight the gap between solubility and in vivo exposure
Academic source · Crystal Growth & Design (ACS)
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Site published: 2026-11-03 · Updated: 2026-11-03
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What changed
Researchers prepared myricetin cocrystals with diprophylline and theobromine and evaluated structure, stability, moisture sensitivity, dissolution, and in vivo absorption. Both forms improved in vitro solubility and reduced hygroscopicity. However, their pharmacokinetic behavior did not simply track the solubility gains, reinforcing the need to assess solid-form performance across laboratory and biological endpoints rather than a single property.
Why it may matter
Cocrystal selection should combine dissolution, phase behavior, and exposure data; higher solubility alone does not establish a superior development candidate.
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