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A branched ionizable lipid nanoparticle platform for versatile in vivo delivery of nucleic acids: Validation from mRNA to capped circular RNA

Academic source · Cell Biomaterials

Source published: 2026-08-19

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

The branched ionizable lipid FL0445 supported delivery of linear mRNA and capped circular RNA through a cholesterol-dependent cellular-entry pathway. In obese mice, GLP-1-encoding capped circular RNA produced sustained expression and improved glucose tolerance relative to tested formulations. Inflammatory transcriptional signals were also assessed. The results provide a preclinical delivery proof of concept, not evidence of clinical metabolic efficacy.

Why this paper is included

Links circular-RNA architecture with carrier selection and duration; mouse metabolic effects do not establish human dosing, safety, or therapeutic benefit.

The interpretation above is analysis, not a conclusion attributed to the original source.

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mRNA / LNP

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