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Overcoming the blood–brain barrier using central nervous system–accessing lipid nanoparticles for enhanced mRNA therapeutics

Academic source · Proceedings of the National Academy of Sciences

Source published: 2026-08-14

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

The CA2d ionizable-LNP platform delivered mRNA to brain cells after intravenous administration in mice and nonhuman primates. Reported target populations included neurons, microglia, and astrocytes. In a rat ischemic-stroke model, combined thrombolytic and neuroprotective mRNA cargos reduced injury and improved functional measures. The work expands preclinical CNS delivery evidence without demonstrating human brain delivery or treatment efficacy.

Why this paper is included

Adds nonhuman-primate evidence for systemic CNS RNA delivery; species differences and neurological safety remain major translational questions.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

mRNA / LNP

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