MAGEA11 recruitment enables selective BET degradation in cancer cell models
Academic source · npj Drug Discovery
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What changed
Researchers developed BET-targeting PROTACs that recruit the tissue-restricted scaffolding protein MAGEA11 rather than relying on widely expressed ligases. Lead compound 105B degraded BET proteins in two cancer cell lines but not in HEK293T cells. Mechanistic experiments implicated MAGEA11 and HUWE1. The authors emphasized that further optimization is needed to produce selective cytotoxicity.
Why it may matter
Tissue-restricted recruitment may offer another route to selectivity, although cellular degradation results do not yet establish an effective therapeutic window.
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