Advancing Charge Detection Mass Spectrometry for Characterizing Large, Intact mRNA Constructs
Academic source · Analytical Chemistry
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
The study develops charge detection mass spectrometry for intact mRNA constructs spanning 997–4,522 nucleotides. Optimized preparation and calibration enabled length determination with 0.5% uncertainty, comparisons of modified nucleotides and poly(A) tails, and analysis after extraction from lipid nanoparticles. The method adds intact-molecule information, while counterion effects and orthogonal identity and impurity measurements remain relevant.
Why this paper is included
Adds an intact-molecule tool for characterization and comparability; release use still requires validating scope and combining it with sequence and impurity assays.
The interpretation above is analysis, not a conclusion attributed to the original source.
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