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AI-driven discovery and engineering of human-derived protein scaffolds for mRNA delivery

Academic source · Nature Communications

Source published: 2026-10-31

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

The DeepDelivery platform screened the human proteome for proteins that could serve as mRNA delivery scaffolds. Twelve of 15 experimentally tested candidates supported particle formation and delivery within a modular system. Engineering TRIM25 domains improved performance. The work establishes a discovery framework in cultured cells, rather than clinical evidence of reduced immunogenicity.

Why this paper is included

Human-derived carriers offer another route to explore repeated dosing, with biodistribution, manufacturing consistency, and immune responses requiring further study.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

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