Optimization of lipid nanoparticles reduces hepatic accumulation and enhances local delivery of mRNA
Academic source · Science China. Life sciences
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
A design-of-experiments approach produced an SM-102-derived formulation with less hepatic reporter expression and preserved or improved expression after local administration. Experiments included intramuscular, intracerebroventricular, and intravitreal routes. Mechanistic analyses associated the change with altered protein binding, systemic exposure, and hepatocyte trafficking. These route-specific results support formulation optimization but do not demonstrate noninvasive access to the brain or eye.
Why this paper is included
Provides a practical strategy to reduce hepatic spillover from local dosing; expression and tolerability findings remain dependent on route and preclinical models.
The interpretation above is analysis, not a conclusion attributed to the original source.
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