Ligand‐Mediated Reprogramming Redirects Liver‐Tropic Ionizable Lipid Nanoparticles for Lung‐Selective mRNA Delivery
Academic source · Angewandte Chemie International Edition
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Starting with a liver-tropic lead from 90 degradable lipidoids, researchers attached small-molecule ligands to redirect delivery toward the lung. The modified particles showed increased vitronectin association and enhanced pulmonary mRNA expression, with genome-editing proof of concept. This modular chemical approach retains the parent scaffold, but its targeting performance remains demonstrated in preclinical experimental conditions.
Why this paper is included
Shows how modest scaffold modification can alter protein-corona interactions and organ targeting; cross-species reproducibility and human selectivity require testing.
The interpretation above is analysis, not a conclusion attributed to the original source.
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