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Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI

Academic source · Nature Biotechnology

Source published: 2026-09-28

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

The AGENT platform combines Bayesian optimization with high-throughput experiments to identify thermostable mRNA-LNP formulations through six iterations in approximately one month. Solid-state model formulations based on SM-102 and ALC-0315 retained biological activity after more than two months at 37°C. Animal immunogenicity supported further development, but these formulation-specific findings do not eliminate cold-chain requirements for mRNA products generally.

Why this paper is included

Illustrates efficient formulation optimization for thermostability; real products require long-term potency, transport, reconstitution, and safety data under their intended conditions.

The interpretation above is analysis, not a conclusion attributed to the original source.

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mRNA / LNP

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