Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing
Academic source · Nature biotechnology
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
A lipid screen explicitly incorporated a large base-editor transcript rather than relying on small reporter RNA. The lead lipid retained favorable RNA interactions and membrane-disrupting structure as cargo size increased. It improved editing in liver, brain, and lung using different administration routes, including intrathecal and intratracheal dosing. The findings do not establish systemic delivery to all three organs.
Why this paper is included
Makes cargo size a practical screening parameter for gene-editing formulations; tissue results depend on administration route and remain preclinical.
The interpretation above is analysis, not a conclusion attributed to the original source.
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