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Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Academic source · Advanced Science

Source published: 2026-07-14

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

A library of 56 ionizable lipids combined biodegradable disulfide linkages with different hydrophobic tail lengths and branching patterns. Structure-activity testing linked tail architecture to endosomal escape, translation, and biocompatibility. Optimized particles reduced cytotoxicity and cytokine induction, with immune-response evaluation extending to a nonhuman primate model. These findings support lipid design, rather than establishing human safety.

Why this paper is included

Offers experimentally grounded tail-chemistry design rules and primate evidence; reduced inflammatory readouts do not guarantee clinical safety.

The interpretation above is analysis, not a conclusion attributed to the original source.

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