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Preparation quality and epitranscriptomic modification influence circular RNA vaccine performance

Academic source · npj Vaccines

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Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

Researchers separated the effects of circular structure, preparation quality, and nucleotide modification across two vaccine antigen systems. Cleaner circular RNA preparations caused less innate immune activation, but antibody and T-cell response levels were comparable with linear mRNA. Incorporating m6A was associated with higher antibody avidity, rather than a general increase in expression.

Why this paper is included

Circular RNA developers should prioritize impurity control and functional immune measurements when evaluating manufacturing choices and claims of platform advantages.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

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