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Retinoic‐Acid‐Derived Ionizable Lipids Enable Spleen‐Selective Antigen Expression for mRNA Cancer Vaccination

Academic source · Angewandte Chemie International Edition

Source published: 2026-08-12

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

A 40-member retinoic-acid-derived ionizable-lipid library yielded AT4-13CRA particles with preferential functional expression in splenic antigen-presenting cells. Researchers linked delivery to altered protein coronas and reduced lysosomal retention. An ovalbumin vaccination model showed stronger antigen-specific immunity and prophylactic tumor protection. The artificial antigen and challenge setting limit direct extrapolation to established human cancers.

Why this paper is included

Supports hydrophobic-domain engineering for APC-centered vaccination; model-antigen prophylactic protection does not establish efficacy against established patient tumors.

The interpretation above is analysis, not a conclusion attributed to the original source.

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