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Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Academic source · Advanced Science

Source published: 2026-07-21

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

Nine bile-acid-derived sterols varied hydroxylation and alkyl-tail chemistry to probe LNP organization and organ expression. Molecular simulations and experiments linked membrane descriptors with encapsulation and formulation behavior. Replacing cholesterol shifted expression toward the spleen, and a lead sterol enhanced antigen-specific responses. The work offers a preclinical formulation framework rather than validated prediction of human biodistribution.

Why this paper is included

Highlights sterols as an independent delivery-design axis; simulation correlations and acute animal tolerability do not establish long-term clinical safety.

The interpretation above is analysis, not a conclusion attributed to the original source.

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mRNA / LNP

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