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Uncovering the lymphatic uptake, pharmacokinetics, and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection

Academic source · Journal of controlled release : official journal of the Controlled Release Society

Source published: 2026-10-26

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

Using three established ionizable lipids, researchers measured RNA, lipid components, lymphatic transport, plasma exposure, and tissue reporter expression in rats. After subcutaneous injection, lymph concentrations exceeded plasma concentrations, but lipid and RNA trafficking did not fully match. The study demonstrates why tracking a lipid label alone may not accurately represent intact RNA delivery or productive expression in tissues.

Why this paper is included

Provides quantitative guidance for distribution studies; rat reporter experiments and single time-point tissue expression cannot fully predict human therapeutic pharmacokinetics.

The interpretation above is analysis, not a conclusion attributed to the original source.

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mRNA / LNP

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