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Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Academic source · Advanced Materials

Source published: 2026-09-27

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

Researchers modified buffer exchange into a two-step dialysis process, first promoting fusion under acidic, higher-ionic-strength conditions while retaining ethanol, then removing ethanol and raising pH. Compared with one-step exchange, the process increased mRNA copies per particle, reduced empty particles, and improved transfection in cells and animals. These formulation-specific results do not establish that removing empties always improves every product.

Why this paper is included

Links particle-level loading with process conditions and function; scale-up requires controlling residual solvent, loading distributions, and consistent performance across batches.

The interpretation above is analysis, not a conclusion attributed to the original source.

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