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2-arm-PEG-Oligocations Transiently Shield the Liver Sinusoids to Mitigate Off-Target Hepatic Expression of mRNA Lipid Nanoparticles

Academic source · ACS Nano

Source published: 2026-08-18

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

Researchers used two-armed PEG conjugated to oligocations to transiently coat liver sinusoidal endothelium before mRNA-LNP exposure. The approach modifies the host delivery barrier rather than the LNP itself, aiming to reduce hepatic entry and off-target expression. Mouse experiments examined reversible coating and clearance. Translation would require evaluating the combined regimen, vascular effects, and repeat-dose safety.

Why this paper is included

Explores host-barrier modulation as a complement to particle engineering; clinical safety cannot be inferred from transient mouse liver shielding.

The interpretation above is analysis, not a conclusion attributed to the original source.

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mRNA / LNP

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