Nanopore-Mediated Assembly Enables Precise and Continuous Synthesis of mRNA-Encapsulated Lipid Nanoparticles for COVID-19 Vaccines
Academic source · ACS Nano
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
A hollow-fiber membrane platform uses dense nanopore arrays to control localized mixing during lipid nanoparticle assembly. The continuous process generated tunable particle sizes, narrow distributions, and high encapsulation, with particle properties linked to membrane pore size. Multiple lipid chemistries and nucleic acid payloads were compatible, and cell and animal studies supported activity. Commercial GMP performance remains to be established.
Why this paper is included
Offers another continuous assembly route; throughput, membrane fouling, cleaning, and comparability require assessment before transferring the platform into a regulated process.
The interpretation above is analysis, not a conclusion attributed to the original source.
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